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Some notes from my game-athon yesterday (took the day off work).
Rebind your keys!!
ASDF for skills instead of 1234 and Space instead of shift for standing still. Man that makes the game like 1000 times more comfortable to play.
Bind the "Move" command to middle mouse button! It's unbound by default. It allows you to move without attacking anything. An absolute must for when you need to immediately wade through a big group of baddies to pick up a health globe. If you were to left click to move to the globe, you'd most likely accidentally attack something and not get the globe in time.
Turn on Elective mode! It should have been on by default. For those that don't know it allows you to put any skill on any of your 4 hotkeys... even two from the same category.
For example having both Ground Stomp and Leap from the defensive category on my barb. That combo is very very powerful. Jump into the middle of a group with Leap, Ground Stomp to Stun everyone then I use Cleave with the exploding enemies perk and everyone dies very very fast.
I've found the best way to attack for my Barb is to just hold down the left click then tap space bar to swing my sword. With the range and slowness of a two handed sword I can time the start of my swing before the mobs are within range and hit them just as they enter, before they can hit me.