Hell yea bro, there is a huge difference in overall LCD quality with the DVI connection vs. analog 9pin. If you are merely browsing the web or typing pages, not much difference. But if you are playing games or watching movies, the DVI input usually cuts down ghosting dramatically, as well as giving overall better color quality.

Although, I've used a Samsung 17in w/ analog and had only slight ghosting with very good image quality. Some companies do it right even with analog, but if I were to buy an LCD there's only good reasons to go with DVI.